Pieter - This is how Charm is designed to work in apps like Keynote. Presentation apps handle their text on a custom canvas rather than the standard text fields most apps use, so instead of rewriting live as you type, Charm corrects them with Fix Selection.
Just highlight the text you'd like to polish up and press Option-Command-V, and Charm cleans up spelling and grammar in one pass. You can change that shortcut in Charm's Settings if you'd prefer a different one.
Give it a try in Keynote and let us know how you get on? Feel free to get in touch if you have any other questions?